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Article

Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype.

Gastroenterology - 1 Nov 2020

Manresa Mario C, Chiang Austin W T, Kurten Richard C, Dohil Ranjan, Brickner Howard, Dohil Lucas, Herro Rana, Akuthota Praveen, Lewis Nathan E, Croft Michael, Aceves Seema S

Abstract excerpt

BACKGROUND & AIMS: Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic disease of the esophagus that involves fibroblast activation and progression to fibrostenosis. Cytokines produced by T-helper type 2 cells and transforming growth factor beta 1 (TGFβ1) contribute to the development of EoE, but other cytokines involved in pathogenesis are unknown. We investigate the effects of tumor necrosis...

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Identifiers

PMID: 32712105
DOI: 10.1053/j.gastro.2020.07.035
PMCID: PMC7726704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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