Article

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160

2021-06-16

Abstract excerpt

HVEM is a TNF (tumor necrosis factor) receptor contributing to a broad range of immune functions involving diverse cell types. It interacts with a TNF ligand, LIGHT, and immunoglobulin (Ig) superfamily members BTLA and CD160. Assessing the functional impact of HVEM binding to specific ligands in different settings has been complicated by the multiple interactions of HVEM and HVEM binding partners. To dissect the m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ea353a3-2723-5721-9f7b-7160a9ae55f7
DOI: 10.1101/2021.06.16.448617

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160DOI 10.1101/2021.06.16.448617Read

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.Semantic proximity Read

Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160.Semantic proximity Read

BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEMSemantic proximity Read

Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathwaySemantic proximity Read

Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability.Semantic proximity Read

A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator.Semantic proximity Read

Genomic Characterization of <i>LIGHT</i> Reveals Linkage to an Immune Response Locus on Chromosome 19p13.3 and Distinct Isoforms Generated by Alternate Splicing or ProteolysisSemantic proximity Read

De novo masking domains that gate TNF-family ligand assembly and activitySemantic proximity Read

Anti-HVEM mAb therapy improves antitumoral immunity both <i>in vitro</i> and <i>in vivo</i> , in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumorsSemantic proximity Read

Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the EyeSemantic proximity Read

Ligand-receptor binding revealed by the TNF family member TALL-1.Semantic proximity Read

Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction.Semantic proximity Read