Article
Understanding and imaging PHGDH-driven intrinsic resistance to mutant IDH inhibition in gliomas
2025-09-04
Abstract excerpt
<h4>ABSTRACT</h4> Mutations in isocitrate dehydrogenase (IDHm) define a distinct molecular class of gliomas. IDHm converts α-ketoglutarate (α-KG) to the oncometabolite D-2-hydroxyglutarate (D-2HG), which drives tumorigenesis. The IDHm inhibitor vorasidenib suppresses D-2HG production and extends progression-free survival in some, but not all, IDHm glioma patients. Here, using clinically relevant patient-derived I...
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Identifiers and source
- Literature Corpus work
- 14df9bb2-b659-540a-b9ab-f8baffd1673d
- DOI
- 10.1101/2025.08.30.673205