Article

The 1p/19q co-deletion induces targetable and imageable vulnerabilities in glucose metabolism in oligodendrogliomas

2025-05-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The 1p/19q co-deletion is a hallmark of oligodendrogliomas. The goal of this study was to exploit metabolic vulnerabilities induced by the 1p/19q co-deletion for oligodendroglioma therapy and non-invasive imaging. <h4>Methods</h4> We used stable isotope tracing, mass spectrometry, and genetic and pharmacological approaches to interrogate [U- 13 C]-glucose metabolism in pat...

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Literature Corpus work: e6c690ea-8a6f-517e-a546-c6c25f0fc3c7
DOI: 10.1101/2025.05.20.655097

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