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Article

Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kinetics.

eLife - 4 Mar 2025

Simoes Rui Vasco, Henriques Rafael Neto, Olesen Jonas L, Cardoso Beatriz M, Fernandes Francisca F, Monteiro Mariana A V, Jespersen Sune N, Carvalho Tânia, Shemesh Noam

Abstract excerpt

Glioblastomas are aggressive brain tumors with dismal prognosis. One of the main bottlenecks for developing more effective therapies for glioblastoma stems from their histologic and molecular heterogeneity, leading to distinct tumor microenvironments and disease phenotypes. Effectively characterizing these features would improve the clinical management of glioblastoma. Glucose flux rates through glycolysis and...

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Topics

Animals
Glioblastoma
Glucose
Mice
Deuterium
Brain Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Disease Models, Animal

Phenotype

Tumor Microenvironment

Kinetics

Glycolysis

Source

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Identifiers

PMID: 40035743
DOI: 10.7554/eLife.100570
PMCID: PMC11879113

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