Article

Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson’s disease

2025-08-11

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Histone deacetylases (HDACs) are epigenetic molecules responsible for regulation of gene transcription. Altered expression of HDACs has been linked to neurodegenerative disease. Here, we used the class I HDAC PET radioligand [ <sup>11</sup> C]Martinostat to quantify and map changes in these molecules in the brain in dementia with Lewy bodies (DLB) and Parki...

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Literature Corpus work: 6e61a076-f774-51dd-8764-7a46e56c9535
DOI: 10.21203/rs.3.rs-6647341/v1

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