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Kinetic Analysis and Quantification of [<sup>11</sup>C]Martinostat for in Vivo HDAC Imaging of the Brain

13 Mar 2015

Abstract excerpt

Epigenetic mechanisms mediated by histone deacetylases (HDACs) have been implicated in a wide-range of CNS disorders and may offer new therapeutic opportunities. In vivo evaluation of HDAC density and drug occupancy has become possible with [(11)C]Martinostat, which exhibits selectivity for a subset of class I/IIb HDAC enzymes. In this study, we characterize the kinetic properties of [(11)C]Martinostat in the...

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Share to Cholinesterase and Neurodegenerative Diseases
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PMID: 25768025
DOI: 10.1021/acschemneuro.5b00066

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