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PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia

9 Dec 2018

Abstract excerpt

BACKGROUND: Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA levels were lower in dorsolateral prefrontal cortex (DLPFC) tissue from donors with SCZ compared with controls. Here we...

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PMID: 30530989
DOI: 10.1172/jci123743

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