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Article

In vivo human brain expression of histone deacetylases in bipolar disorder

8 Jul 2020

Abstract excerpt

Abstract The etiology of bipolar disorder (BD) is unknown and the neurobiological underpinnings are not fully understood. Both genetic and environmental factors contribute to the risk of BD, which may be linked through epigenetic mechanisms, including those regulated by histone deacetylase (HDAC) enzymes. This study measures in vivo HDAC expression in individuals with BD for the first time using the HDAC-specific...

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PMID: 32641695
DOI: 10.1038/s41398-020-00911-5

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