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High-Contrast PET imaging with [ <sup>18</sup> F]-NT160, a Class-IIa Histone Deacetylase (Class-IIa HDAC) Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System

2022-11-13

Abstract excerpt

We utilized positron emission tomography (PET) imaging in vivo to map the spatiotemporal biodistribution/expression (protein density) of class-IIa histone deacetylases (class-IIa HDACs) in the brain. Herein, we report an improved radiosynthesis of [ 18 F]-NT160 using 4-hydroxy-TEMPO which led to a significant improvement in radiochemical yield and molar activity. PET imaging with [ 18 F]-NT160, a highly potent...

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Literature Corpus work
af3c93fe-db65-55d2-a14e-cedc56a0bc8c
DOI
10.1101/2022.11.12.516260
Open publication

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High-Contrast PET imaging with [ <sup>18</sup> F]-NT160, a Class-IIa Histone Deacetylase (Class-IIa HDAC) Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous SystemDOI 10.1101/2022.11.12.516260
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