Article

Drug screening linked to molecular profiling identifies novel dependencies in patient-derived primary cultures of paediatric high grade glioma and DIPG

2020-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Paediatric high grade glioma and diffuse midline glioma (including DIPG) are comprised of multiple biological and clinical subgroups, the majority of which urgently require novel therapies. Patient-derived in vitro primary cell cultures represent potentially useful tools for mechanistic and preclinical investigation based upon their retention of key features of tumour subgroups under experiment...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e5b64f6-1203-5b1f-bb86-e43d52d51d29
DOI: 10.1101/2020.12.29.424674

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug screening linked to molecular profiling identifies novel dependencies in patient-derived primary cultures of paediatric high grade glioma and DIPGDOI 10.1101/2020.12.29.424674Read

Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug ResponseSemantic proximity Read

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.Semantic proximity Read

Functional genomics identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomasSemantic proximity Read

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.Semantic proximity Read

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell LinesSemantic proximity Read

Real-time drug testing of paediatric diffuse midline glioma to support clinical decision making: The Zurich DIPG/DMG centre experience.Semantic proximity Read

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicineSemantic proximity Read

Multi-omics and pharmacological characterization of patient-derived glioma cell linesSemantic proximity Read

Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell culturesSemantic proximity Read

PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo.Semantic proximity Read

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomasSemantic proximity Read

Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumorsSemantic proximity Read