Article
Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.
PloS one - 1 Jan 2009
Bax Dorine A, Little Suzanne E, Gaspar Nathalie, Perryman Lara, Marshall Lynley, Viana-Pereira Marta, Jones Tania A, Williams Richard D, Grigoriadis Anita, Vassal Gilles, Workman Paul, Sheer Denise, Reis Rui M, Pearson Andrew D J, Hargrave Darren, Jones Chris
Abstract excerpt
BACKGROUND: Although paediatric high grade gliomas resemble their adult counterparts in many ways, there appear to be distinct clinical and biological differences. One important factor hampering the development of new targeted therapies is the relative lack of cell lines derived from childhood glioma patients, as it is unclear whether the well-established adult lines commonly used are representative of the...
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