Article

NOSTRIN is an emerging negative regulator of decompensated cirrhotic patients with portal hypertension

2024-05-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background and aims:</bold> Decreased nitric oxide (NO) bioavailability in a cirrhotic liver contributes to high intrahepatic vascular resistance (IHVR) and portal hypertension (PHT). Nostrin is an inhibitory protein of NO synthesising enzyme endothelial NO synthase (eNOS), shown to increase in cirrhosis with PHT, however, the precise molecular mechanism is poorly documented. This...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e532a54-d009-5a4a-b908-0528c0867b4b
DOI: 10.21203/rs.3.rs-4327525/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NOSTRIN is an emerging negative regulator of decompensated cirrhotic patients with portal hypertensionDOI 10.21203/rs.3.rs-4327525/v1Read

Increased gene and protein expression of the novel eNOS regulatory protein NOSTRIN and a variant in alcoholic hepatitis.Semantic proximity Read

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.Semantic proximity Read

Involvement of nitric oxide and its up/down stream molecules in the immunity against parasitic infectionsSemantic proximity Read

The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular healthSemantic proximity Read

Functional variants of eNOS and iNOS genes have no relationship to the portal hypertension in patients with liver cirrhosis.Semantic proximity Read

Role of endothelial nitric oxide synthase in the development of portal hypertension in the carbon tetrachloride-induced liver fibrosis model.Semantic proximity Read

The role of the eNOS G894T and T-786C gene polymorphism in the development of ascites in cirrhosis.Semantic proximity Read

Abnormal Expression of NOS3 and Association with Clinical Outcome are Highly Cancer Dependent as Revealed through Pan-Cancer AnalysisSemantic proximity Read

Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxideSemantic proximity Read

Regulation of cytochrome P450 enzyme activity and expression by nitric oxide in the context of inflammatory diseaseSemantic proximity Read

Genetic variants of endothelial nitric oxide synthase in patients with primary biliary cirrhosis: association with disease severity.Semantic proximity Read

Acute Liver Failure in Rats Induced Vasogenic Edema and Nitric Oxide Synthase-Nitric Oxide-cGMP Pathway after Differential Regulation of NMDA Receptors in Cerebral Cortex and CerebellumSemantic proximity Read