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Regulation of cytochrome P450 enzyme activity and expression by nitric oxide in the context of inflammatory disease

8 Sept 2020

Abstract excerpt

Many hepatic cytochrome P450 enzymes and their associated drug metabolizing activities are down-regulated in disease states, and much of this has been associated with inflammatory cytokines and their signaling pathways. One such pathway is the induction of inducible nitric oxide synthase (NOS2) and generation of nitric oxide (NO) in many tissues and cells including the liver and hepatocytes. Experiments in the...

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PMID: 32898444
DOI: 10.1080/03602532.2020.1817061

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