Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide

Abstract excerpt

Nitric oxide (NO) is a small gas molecule derived from at least three isoforms of the enzyme termed nitric oxide synthase (NOS). More than 15 years ago, the question of feedback regulation of NOS activity and expression by its own product was raised. Since then, a number of trials have verified the existence of negative feedback loop both in vitro and in vivo. NO, whether released from exogenous donors or applied...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Eicosanoids and Hypertension Pharmacology
• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Share to Nitric Oxide and Endothelin Effects