Article
Functional variants of eNOS and iNOS genes have no relationship to the portal hypertension in patients with liver cirrhosis.
Scandinavian journal of gastroenterology - 1 May 2013
Petrtyl Jaromir, Dvorak Karel, Jachymova Marie, Vitek Libor, Lenicek Martin, Urbanek Petr, Linhart Ales, Jansa Pavel, Bruha Radan
Abstract excerpt
OBJECTIVE: Nitric oxide is an important vasoactive mediator. Changes in NO production, caused by functional variants of both endothelial and inducible NO synthase (eNOS, iNOS), might play a role in portal hypertension. The aim was to study the significance of functional eNOS and iNOS gene variants in cirrhotic patients and their interrelationship to both inflammatory and endothelial activation parameters....
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