Article

Chronic IFNα treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring

2022-10-21

Abstract excerpt

Although clinically effective, the actions of IFNα, either produced endogenously or by therapeutic delivery, remain poorly understood. Emblematic of this research gap is the disparate array of notable side effects that occur in susceptible individuals, such as neuropsychiatric consequences, autoimmune phenomena, and infectious complications. We hypothesised that these complications are driven at least in part by d...

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Literature Corpus work: 6e51126c-1e18-5c93-9177-b13159f92563
DOI: 10.1101/2022.10.17.512487

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