Back to search

Article

Genetic Variability in the IGF-1 Axis Modulates Cancer-Associated Cachexia and Prognosis

2026-03-31

Abstract excerpt

Cancer-associated cachexia (CAC) is a multifactorial syndrome driven by a profound metabolic and inflammatory dysregulation. Due to the central role of the insulin growth factor 1 (IGF-1) pathway in regulating muscle mass, energy metabolism, and inflammation, this study evaluated the relevance of IGF-1 axis-related genetic variants to CAC onset and their impact on overall survival (OS) in a cohort of 140 cancer pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6e506fc2-7bf4-56fa-8b2c-b38058bc7427
DOI
10.20944/preprints202603.2428.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genetic Variability in the IGF-1 Axis Modulates Cancer-Associated Cachexia and PrognosisDOI 10.20944/preprints202603.2428.v1
Genetic Variation in the Oestrogen Pathway and Cancer-Associated Cachexia: Implications for Disease Predictive and Supportive CareSemantic proximity
Vitamin D Receptor rs731236 Polymorphism Modulates Cancer Cachexia Susceptibility and Overall Survival: A Real-World Study on Context-Dependent Vitamin D Signalling.Semantic proximity
Vitamin D Receptor rs731236 Polymorphism Modulates Cancer Cachexia Susceptibility and Overall Survival: A Real-World Study on Context- Dependent Vitamin D SignallingSemantic proximity
Genetic Variants in Metabolic Signaling Pathways and Their Interaction with Lifestyle Factors on Breast Cancer Risk: A Random Survival Forest Analysis.Semantic proximity
Genetic basis of interindividual susceptibility to cancer cachexia: selection of potential candidate gene polymorphisms for association studies.Semantic proximity
A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence.Semantic proximity
Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX.Semantic proximity
Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma.Semantic proximity
Clusters of Anthropometric Features in Colorectal Cancer Patients with Synchronous Metastases and Their Association with Overall Survival and RAS Mutation.Semantic proximity
Unveiling the role of FTO polymorphisms in predicting response to immune checkpoint inhibitors: A retrospective study.Semantic proximity
Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers.Semantic proximity
Exploring the impact of body mass index on tumor biology and cancer developmentSemantic proximity
Select a neighboring publication to make it the new centre.