Article
Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma.
Carcinogenesis - 17 Apr 2021
Dighe Shruti G, Chen Jianhong, Yan Li, He Qianchuan, Gharahkhani Puya, Onstad Lynn, Levine David M, Palles Claire, Ye Weimin, Gammon Marilie D, Iyer Prasad G, Anderson Lesley A, Liu Geoffrey, Wu Anna H, Dai James Y, Chow Wong-Ho, Risch Harvey A, Lagergren Jesper, Shaheen Nicholas J, Bernstein Leslie, Corley Douglas A, Prenen Hans, deCaestecker John, MacDonald David, Moayyedi Paul, Barr Hugh, Love Sharon B, Chegwidden Laura, Attwood Stephen, Watson Peter, Harrison Rebecca, Ott Katja, Moebus Susanne, Venerito Marino, Lang Hauke, Mayershofer Rupert, Knapp Michael, Veits Lothar, Gerges Christian, Weismüller Josef, Gockel Ines, Vashist Yogesh, Nöthen Markus M, Izbicki Jakob R, Manner Hendrik, Neuhaus Horst, Rösch Thomas, Böhmer Anne C, Hölscher Arnulf H, Anders Mario, Pech Oliver, Schumacher Brigitte, Schmidt Claudia, Schmidt Thomas, Noder Tania, Lorenz Dietmar, Vieth Michael, May Andrea, Hess Timo, Kreuser Nicole, Becker Jessica, Ell Christian, Ambrosone Christine B, Moysich Kirsten B, MacGregor Stuart, Tomlinson Ian, Whiteman David C, Jankowski Janusz, Schumacher Johannes, Vaughan Thomas L, Madeleine Margaret M, Hardie Laura J, Buas Matthew F
Abstract excerpt
Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is...
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