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Article

Vitamin D Receptor rs731236 Polymorphism Modulates Cancer Cachexia Susceptibility and Overall Survival: A Real-World Study on Context-Dependent Vitamin D Signalling.

International journal of molecular sciences - 27 Jun 2026

Tavares Valéria, Silva Ana Carolina Leão, Xavier Anna Flávia, de Melo Inês Guerra, Ferreira Tiago, Pires Mariana Moreira, Silva Cláudia, Dias Virgínia Rocha, Silva Maria Paula, Santos Joana M O, Medeiros Rui

Abstract excerpt

Cancer-associated cachexia (CAC) is a complex metabolic syndrome characterised by progressive skeletal muscle loss, systemic inflammation, reduced treatment tolerance, and poor survival. Marked interindividual variability in CAC susceptibility suggests that host genetic factors may contribute to its development. Vitamin D plays an important role in muscle metabolism and inflammatory control through activation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42450089
DOI: 10.3390/ijms27135816
PMCID: PMC13361905

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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