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Article

Sleep Duration and Epilepsy Risk: Mendelian Randomization and Functional Validation of CACNA1A rs2228130-Related Inhibitory Synaptic Dysfunction.

Neuromolecular medicine - 20 Jul 2026

Li Xun, Hou Yuying, Ren Yanping, Yue Wei

Abstract excerpt

Objectives To evaluate the causal association between sleep traits and epilepsy risk using Mendelian randomization, and to investigate the mechanism of a prioritized epilepsy-risk variant through gene-level enrichment analysis and functional validation. Methods Large-scale European GWAS datasets were analysed using multiple Mendelian randomization methods, including inverse variance weighted, MR-Egger and...

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Identifiers

PMID: 42474867
DOI: 10.1007/s12017-026-08943-8

Genes

CACNA1A

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