Article

Aneuploidy in human embryos is associated with a maternal age-independent increase in mitochondrial DNA content and an enrichment of ultra-rare mitochondrial DNA variants

2022-10-18

Abstract excerpt

<h4>ABSTRACT</h4> Using low-coverage, whole-genome sequences of trophectoderm biopsies from 11,610 human blastocyst-stage embryos, we analyzed the relationship between chromosomal abnormalities and mitochondrial (mt) DNA dynamics. Comparing 6,208 aneuploid and 5,402 euploid embryos in cohort studies, we found that mtDNA content in aneuploid embryos was significantly higher than that in euploid embryos. This outco...

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Literature Corpus work: 6e272bee-0481-5f47-bb01-8637c205032b
DOI: 10.1101/2022.10.14.512116

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