Article

The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility

2025-05-12

Abstract excerpt

Cancer cells develop unique addictions to nutrients, offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundamental open questions. Here, we developed a systematic framework to investigate nutrient dependencies and applied it to study glutamine addiction. By measuring metabolite exchange rates across 54 cancer cell lines wit...

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Literature Corpus work: 6e078a0a-7874-5edd-b129-7ab4a6acf8be
DOI: 10.1101/2025.05.12.652188

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