Article

Drug-tolerant idling melanoma cells exhibit theory-predicted metabolic low-low phenotype

2019-10-17

Abstract excerpt

Cancer cells adjust their metabolic profiles to evade treatment. Metabolic adaptation is complex and hence better understood by an integrated theoretical-experimental approach. Using a minimal kinetic model, we predicted a previously undescribed Low/Low (L/L) phenotype, characterized by low oxidative phosphorylation (OXPHOS) and low glycolysis. Here, we report that L/L metabolism is observed in BRAF -mutated mela...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6def0092-82de-5e3c-a9a3-4b7101f22e6c
DOI: 10.1101/809889

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug-tolerant idling melanoma cells exhibit theory-predicted metabolic low-low phenotypeDOI 10.1101/809889Read

Metabolic rewiring in melanoma drug-resistant cells.Semantic proximity Read

Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors.Semantic proximity Read

Multi-omics-driven kinetic modeling reveals metabolic adaptations and vulnerabilities in BRCA1-deficient ovarian cancerSemantic proximity Read

Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanomaSemantic proximity Read

Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition.Semantic proximity Read

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance.Semantic proximity Read

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell lineSemantic proximity Read

ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanomaSemantic proximity Read

Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associationsSemantic proximity Read

Trajectories from Snapshots: Integrated proteomic and metabolic single-cell assays reveal multiple independent adaptive responses to drug tolerance in a BRAF-mutant melanoma cell lineSemantic proximity Read

Metabolic rewiring in melanoma.Semantic proximity Read

Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanomaSemantic proximity Read