Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations

Abstract excerpt

<h4>Summary</h4> Targeting the distinct metabolic needs of tumor cells has recently emerged as a promising strategy for cancer therapy. The heterogeneous, context-dependent nature of cancer cell metabolism, however, poses challenges in identifying effective therapeutic interventions. Here, we utilize various unsupervised and supervised multivariate modeling approaches to systematically pinpoint recurrent metaboli...

Topics

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• Gene Amplification
• Genotype
• Metabolic Networks and Pathways
• Mutation
• Neoplasms
• Oncogenes
• Phenotype
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

2047c93e-0845-5013-a060-8f8f4ad8c351

DOI

10.1101/2023.11.28.569098