Article

ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanoma

2022-10-21

Abstract excerpt

Metabolic reprogramming is an emerging hallmark of resistance to cancer therapy but may generate vulnerabilities that can be targeted with small molecules. Multi-omics analysis revealed that NRAS-mutated melanoma cells with a mesenchymal transcriptional profile adopt a quiescent metabolic program to resist cellular stress response induced by MEK-inhibitor resistance. However, as a result of elevated baseline ROS l...

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Literature Corpus work: efeae16d-55bf-5fe8-8bb0-bdce3797db7d
DOI: 10.1101/2022.10.19.512839

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