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Article

Clonal expansions of CD4 + B helper T cells in autoimmune myasthenia gravis

26 Feb 2007

Abstract excerpt

The weakness in myasthenia gravis (MG) is mediated by T helper cell (Th)-dependent autoantibodies against neuromuscular epitopes. So far, analyzing Th phenotypes or antigen specificities has yielded very few clues to pathogenesis. Here we adopt an alternative antigen-independent approach, analyzing T cell receptor (TCR) Vbeta usage/expansions in blood from 118 MG patients. We found major expansions (>or= five...

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PMID: 17323412
DOI: 10.1002/eji.200636449

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