Article

The Effect of ARHGEF15 Knockout and Forebrain-Specific Human ARHGEF15 Knock-In on Seizure Susceptibility in Mice

2021-06-10

Abstract excerpt

<h4>Background: </h4> The ARHGEF15 gene encodes the Rho guanine nucleotide exchange factor 15. Although multiple evidence indicates that ARHGEF15 may be related to epilepsy, it is not clear what role it plays. Methods Subjects were homozygous ARHGEF15 knockout (E5 −/− ) mice, wild-type (WT) mice, Cre-positive homozygous human ARHGEF15 conditional knock-in (E5 CKI/CKI •Cre+) mice which can overexpress human Ephexi...

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Literature Corpus work: 6dd0a743-70b0-5353-9996-f241baf82312
DOI: 10.21203/rs.3.rs-517904/v1

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