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Article

RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells

2022-04-15

Abstract excerpt

<title>Abstract</title> <p>Breast cancer stem cells (BCSC) are presumed to be responsible for treatment resistance, tumor recurrence and metastasis of breast tumors. However, development of BCSC-targeting therapies has been held back by their heterogeneity and the lack of BCSC-selective molecular targets. Here, we demonstrate that Rac1b, the only known alternatively spliced variant of the small GTPase Rac1, is ex...

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Literature Corpus work
cb9754c6-7d9a-5408-af40-a9997be9ac43
DOI
10.21203/rs.3.rs-1343371/v1
Open publication

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RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cellsDOI 10.21203/rs.3.rs-1343371/v1
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