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Rack1 promotes breast cancer stemness properties and tumorigenesis through the E2F1-SOX2 axis

12 Feb 2025

Abstract excerpt

BACKGROUND: Breast cancer remains the most prevalent malignancy and the leading cause of cancer-related mortality among women worldwide. The primary factors contributing to the deterioration and death of patients with breast cancer are metastasis, recurrence, and drug resistance. These phenomena are closely related to the presence of breast cancer stem cells; however, the exact mechanisms regulating stemness...

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PMID: 39939870
DOI: 10.1186/s12935-025-03678-1

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