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Article

The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure.

The Journal of biological chemistry - 29 Sept 2017

McQueen Allison E, Kanamaluru Deepthi, Yan Kimberly, Gray Nora E, Wu Leslie, Li Mei-Lan, Chang Anthony, Hasan Adeeba, Stifler Daniel, Koliwad Suneil K, Wang Jen-Chywan

Abstract excerpt

Angptl4 (Angiopoietin-like 4) is a circulating protein secreted by white and brown adipose tissues and the liver. Structurally, Angptl4 contains an N-terminal coiled-coil domain (CCD) connected to a C-terminal fibrinogen-like domain (FLD) via a cleavable linker, and both full-length Angptl4 and its individual domains circulate in the bloodstream. Angptl4 inhibits extracellular lipoprotein lipase (LPL) activity...

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Share to Abdominal Fat
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28842503
DOI: 10.1074/jbc.M117.803973
PMCID: PMC5625043

Genes

LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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