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Article

Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue

3 Jun 2020

Abstract excerpt

OBJECTIVE: Studies in mice have shown that the decrease in lipoprotein lipase (LPL) activity in adipose tissue upon fasting is mediated by induction of the inhibitor ANGPTL4. Here, we aimed to validate this concept in humans by determining the effect of a prolonged fast on ANGPTL4 and LPL gene and protein expression in human subcutaneous adipose tissue. METHODS: Twenty-three volunteers ate a standardized meal at...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 32504883
DOI: 10.1016/j.molmet.2020.101033

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