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Article

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis.

JCI insight - 22 Mar 2018

Aryal Binod, Singh Abhishek K, Zhang Xinbo, Varela Luis, Rotllan Noemi, Goedeke Leigh, Chaube Balkrishna, Camporez Joao-Paulo, Vatner Daniel F, Horvath Tamas L, Shulman Gerald I, Suárez Yajaira, Fernández-Hernando Carlos

Abstract excerpt

Alterations in ectopic lipid deposition and circulating lipids are major risk factors for developing cardiometabolic diseases. Angiopoietin-like protein 4 (ANGPTL4), a protein that inhibits lipoprotein lipase (LPL), controls fatty acid (FA) uptake in adipose and oxidative tissues and regulates circulating triacylglycerol-rich (TAG-rich) lipoproteins. Unfortunately, global depletion of ANGPTL4 results in severe...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

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Source

Open in PubMed Open full text

Identifiers

PMID: 29563332
DOI: 10.1172/jci.insight.97918
PMCID: PMC5926923

Genes

ANGPTL4
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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