Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.

doi:10.1073/pnas.0705041104

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Article

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2007

Desai Urvi, Lee E-Chiang, Chung Kyu, Gao Cuihua, Gay Jason, Key Billie, Hansen Gwenn, Machajewski Dennis, Platt Kenneth A, Sands Arthur T, Schneider Matthias, Van Sligtenhorst Isaac, Suwanichkul Adisak, Vogel Peter, Wilganowski Nat, Wingert June, Zambrowicz Brian P, Landes Greg, Powell David R

Abstract excerpt

We used gene knockout mice to explore the role of Angiopoietin-like-4 (Angptl4) in lipid metabolism as well as to generate anti-Angptl4 mAbs with pharmacological activity. Angptl4 -/- mice had lower triglyceride (TG) levels resulting both from increased very low-density lipoprotein (VLDL) clearance and decreased VLDL production and had modestly lower cholesterol levels. Also, both Angptl4 -/- suckling mice and...

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PMID: 17609370
DOI: 10.1073/pnas.0705041104
PMCID: PMC1913890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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