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Article

Neomorphic mutations create therapeutic challenges in cancer.

Oncogene - 23 Mar 2017

Takiar V, Ip C K M, Gao M, Mills G B, Cheung L W T

Abstract excerpt

Oncogenesis is a pathologic process driven by genomic aberrations, including changes in nucleotide sequences. The majority of these mutational events fall into two broad categories: inactivation of tumor suppressor genes (hypomorph, antimorph or amorph) or activation of oncogenes (hypermorph). The recent surge in genome sequence data and functional genomics research has ushered in the discovery of aberrations in...

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Identifiers

PMID: 27841866
DOI: 10.1038/onc.2016.312
PMCID: PMC6609160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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