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Article

BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality.

Genes & development - 7 Jan 2025

Khalizieva Anna, Moser Sarah C, Bouwman Peter, Jonkers Jos

Abstract excerpt

The discovery of BRCA1 and BRCA2 as tumor susceptibility genes and their role in genome maintenance has transformed our understanding of hereditary breast and ovarian cancer. This review traces the evolution of BRCA1/2 research over the past 30 years, highlighting key discoveries in the field and their contributions to tumor development. Additionally, we discuss current preventive measures for BRCA1/2 mutation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Source

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Identifiers

PMID: 39510841
DOI: 10.1101/gad.352083.124
PMCID: PMC11789497

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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