Genomic and immune profiling of pre-invasive lung adenocarcinoma.

doi:10.1038/s41467-019-13460-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genomic and immune profiling of pre-invasive lung adenocarcinoma.

Nature communications - 29 Nov 2019

Chen Haiquan, Carrot-Zhang Jian, Zhao Yue, Hu Haichuan, Freeman Samuel S, Yu Su, Ha Gavin, Taylor Alison M, Berger Ashton C, Westlake Lindsay, Zheng Yuanting, Zhang Jiyang, Ramachandran Aruna, Zheng Qiang, Pan Yunjian, Zheng Difan, Zheng Shanbo, Cheng Chao, Kuang Muyu, Zhou Xiaoyan, Zhang Yang, Li Hang, Ye Ting, Ma Yuan, Gao Zhendong, Tao Xiaoting, Han Han, Shang Jun, Yu Ying, Bao Ding, Huang Yechao, Li Xiangnan, Zhang Yawei, Xiang Jiaqing, Sun Yihua, Li Yuan, Cherniack Andrew D, Campbell Joshua D, Shi Leming, Meyerson Matthew

Abstract excerpt

Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood. Here we report exome and transcriptome sequencing of 98 lung adenocarcinoma precursor lesions and 99 invasive adenocarcinomas. We have identified EGFR, RBM10, BRAF, ERBB2, TP53, KRAS, MAP2K1 and MET as significantly mutated genes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to MAP Kinase Kinase 1

Share to Neoplasm Invasiveness

Share to Proto-Oncogene Proteins c-met

Share to Receptor, ErbB-2

Share to Receptors, Antigen, B-Cell

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 31784532
DOI: 10.1038/s41467-019-13460-3
PMCID: PMC6884501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic and immune profiling of pre-invasive lung adenocarcinoma.PMID 31784532Read ↗

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesionsSemantic proximity Read ↗

An Investigation of the Immune Microenvironment and Genome during Lung Adenocarcinoma DevelopmentSemantic proximity Read ↗

Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular featuresSemantic proximity Read ↗

Genomic Underpinnings of Tumor Behavior in In Situ and Early Lung Adenocarcinoma.Semantic proximity Read ↗

Up-regulated tumor intrinsic growth potential and decreased immune function orchestrate the evolution of lung adenocarcinomaSemantic proximity Read ↗

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.Semantic proximity Read ↗

Integrated whole-exome and bulk transcriptome sequencing delineates the dynamic evolution from preneoplasia to invasive lung adenocarcinoma featured with ground-glass nodules.Semantic proximity Read ↗

Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma.Semantic proximity Read ↗

Evolutionary proteogenomic landscape from pre-invasive to invasive lung adenocarcinomaSemantic proximity Read ↗

Lung adenocarcinoma WHO histological classes contain distinct immune cell profilesSemantic proximity Read ↗

Genomic Alterations in the RB Pathway Indicate Prognostic Outcomes of Early-Stage Lung Adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.