Article

<i>In vitro</i> evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

2021-02-10

Abstract excerpt

Remdesivir (RDV) is used widely for COVID-19 patients despite varying results in recent clinical trials. Here, we show how serially passaging SARS-CoV-2 in vitro in the presence of RDV selected for drug-resistant viral populations. We determined that the E802D mutation in the RNA-dependent RNA polymerase was sufficient to confer decreased RDV sensitivity without affecting viral fitness. Analysis of more than 200,...

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Literature Corpus work: 6d719dd5-6e17-53de-9435-978b9f5ce7b8
DOI: 10.1101/2021.02.01.429199

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