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Article

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2.

PLoS pathogens - 1 Sept 2021

Szemiel Agnieszka M, Merits Andres, Orton Richard J, MacLean Oscar A, Pinto Rute Maria, Wickenhagen Arthur, Lieber Gauthier, Turnbull Matthew L, Wang Sainan, Furnon Wilhelm, Suarez Nicolas M, Mair Daniel, da Silva Filipe Ana, Willett Brian J, Wilson Sam J, Patel Arvind H, Thomson Emma C, Palmarini Massimo, Kohl Alain, Stewart Meredith E

Abstract excerpt

Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports identifying SARS-CoV-2 RDV resistance in patients, animal models or in vitro. Here, we selected drug-resistant viral populations by serially passaging SARS-CoV-2 in vitro in the presence of RDV. Using high throughput sequencing, we...

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Adenosine Monophosphate
Alanine
Chlorocebus aethiops
COVID-19 Drug Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Microbial

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 34534263
DOI: 10.1371/journal.ppat.1009929
PMCID: PMC8496873

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