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Article

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.

Science translational medicine - 3 Aug 2022

Stevens Laura J, Pruijssers Andrea J, Lee Hery W, Gordon Calvin J, Tchesnokov Egor P, Gribble Jennifer, George Amelia S, Hughes Tia M, Lu Xiaotao, Li Jiani, Perry Jason K, Porter Danielle P, Cihlar Tomas, Sheahan Timothy P, Baric Ralph S, Götte Matthias, Denison Mark R

Abstract excerpt

The nucleoside analog remdesivir (RDV) is a Food and Drug Administration-approved antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Thus, it is critical to understand factors that promote or prevent RDV resistance. We passaged SARS-CoV-2 in the presence of increasing concentrations of GS-441524, the parent nucleoside of RDV. After 13 passages, we isolated three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35482820
DOI: 10.1126/scitranslmed.abo0718
PMCID: PMC9097878

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