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Article

The impact of remdesivir on SARS-CoV-2 evolution in vivo.

JCI insight - 21 Jan 2025

Ling-Hu Ted, Simons Lacy M, Rios-Guzman Estefany, Carvalho Alexandre Machado, Agnes Maria Francesca R, Alisoltanidehkordi Arghavan, Ozer Egon A, Lorenzo-Redondo Ramon, Hultquist Judd F

Abstract excerpt

The impact of remdesivir on SARS-CoV-2 diversity and evolution in vivo has remained unclear. In this single-center, retrospective cohort study, we assessed SARS-CoV-2 diversification and diversity over time in a cohort of hospitalized patients who did or did not receive remdesivir. Whole-genome sequencing was performed on 98 paired specimens collected from 49 patients before and after remdesivir administration....

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Adenosine Monophosphate
Alanine
COVID-19
COVID-19 Drug Treatment
Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Nonstructural Proteins

Whole Genome Sequencing

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Identifiers

PMID: 39836474
DOI: 10.1172/jci.insight.182376
PMCID: PMC11949014

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