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Limited Short-Term Evolution of SARS-CoV-2 RNA-Dependent RNA Polymerase under Remdesivir Exposure in Upper Respiratory Compartments.

Viruses - 24 Sept 2024

Novitsky Vladimir, Beckwith Curt G, Carpenter-Azevedo Kristin, Shin Jimin, Hague Joel, Sam Soya, Steingrimsson Jon, Huard Richard C, Lethbridge Kevin, Sahu Sujata, Rapoza Kim, Chandran Karen, Bazerman Lauri, Hipolito Evelyn, Diaz Isabella, Carnevale Daniella, Guang August, Gillani Fizza, Caliendo Angela M, Kantor Rami

Abstract excerpt

BACKGROUND: The extent of the SARS-CoV-2 short-term evolution under Remdesivir (RDV) exposure and whether it varies across different upper respiratory compartments are not fully understood. METHODS: Patients hospitalized for COVID-19, with or without RDV therapy, were enrolled and completed up to three visits, in which they provided specimens from four respiratory compartments. Near full-length genome SARS-CoV-2...

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PMID: 39459846
DOI: 10.3390/v16101511
PMCID: PMC11512361

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