Article
An evolving cancer instigates clonally unrelated neighboring cells to form distant metastases
2016-11-03
Abstract excerpt
Based on the clonal evolution theory of cancer formation, a single cell within a tissue gains a cancer-driving mutation and thus a growth advantage. From this expanded cellular mass, another cell gains a new mutation allowing this newly mutated cell to gain new competitive advantage and to expand in number (thus clonal expansion). Another clone then emerges. Eventually all required mutations are gained, and a canc...
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Identifiers and source
- Literature Corpus work
- 6d7067cf-7e96-5829-bebc-83005d8ebb9c
- DOI
- 10.1101/085423