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Natural and chemotherapy-induced clonal evolution of tumors

1 Apr 2017

Abstract excerpt

Evolution and natural selection of tumoral clones in the process of transformation and the following carcinogenesis can be called natural clonal evolution. Its main driving factors are internal: genetic instability initiated by driver mutations and microenvironment, which enables selective pressure while forming the environment for cell transformation and their survival. We present our overview of contemporary...

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Identifiers

PMID: 28371598
DOI: 10.1134/s0006297917040022

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