Article
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
Biomolecules - 23 Jul 2021
Wang Shirong, Cao Qiang, Cui Xin, Jing Jia, Li Fenfen, Shi Huidong, Xue Bingzhong, Shi Hang
Abstract excerpt
Increasing energy expenditure through activation of brown fat thermogenesis is a promising therapeutic strategy for the treatment of obesity. Epigenetic regulation has emerged as a key player in regulating brown fat development and thermogenic program. Here, we aimed to study the role of DNA methyltransferase 3b (Dnmt3b), a DNA methyltransferase involved in de novo DNA methylation, in the regulation of brown fat...
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