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Drugs that act on both GPCRs and kinases: Potentiation of effects, side effects and general aspects of drug pleiotropy

2025-12-31

Abstract excerpt

<h4>Background: </h4> A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This phenomenon has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate, that act on various proteins in humans. Furthermore, several drugs act on multiple proteins without a...

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Literature Corpus work
6d50bb91-442b-5f99-88f0-420f4f0af752
DOI
10.22541/au.176718976.62475551/v1
Open publication

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