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Article

Why medicines work.

Pharmacology & therapeutics - 1 Oct 2022

Swinney David C

Abstract excerpt

The interactions of candidate medicines with physiology that have yielded therapeutics are a small subset of the total interactions investigated. To be useful the interactions must initiate molecular actions that fix a disease phenotype. While much is known about the targets for successful interactions and the disease phenotypes, much less is understood of the molecular actions that connect the initial...

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PMID: 35351464
DOI: 10.1016/j.pharmthera.2022.108175

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