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Article

Unintended Effects of GPCR-Targeted Drugs on the Cancer Phenotype.

Trends in pharmacological sciences - 1 Dec 2020

Cornwell Abigail C, Feigin Michael E

Abstract excerpt

G protein-coupled receptors (GPCRs) are the most common class of therapeutic targets, accounting for ~35% of all FDA-approved drugs. Cancer patients receive numerous medications not only to combat cancer but also to alleviate pain, nausea, and anxiety, many of which target GPCRs. Emerging evidence has implicated GPCRs as drivers of cancer progression, therapeutic resistance, and metastasis. Therefore, the effects...

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Identifiers

PMID: 33198923
DOI: 10.1016/j.tips.2020.10.001
PMCID: PMC7672258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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