Article

BARNO: a batch-aware regulatory network optimization framework reveals a RAN-ENO1-NONO regulatory core in melanoma

2026-03-24

Abstract excerpt

<title>Abstract</title> <p>High-quality melanoma datasets reported by Livnat et al. in 2018 provide an important opportunity to study treatment-associated regulatory programs in patient-derived tumors, yet batch effects often confound regulatory inference and obscure true biological rewiring. Here we present BARNO (Batch-Aware Regulatory Network Optimization), a GENIE3-based framework that penalizes transcription...

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Literature Corpus work: 6d4310d5-bfbf-5e1f-a81b-2e5296195a77
DOI: 10.21203/rs.3.rs-9142292/v1

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