Article

Loss of the homologous recombination gene <i>rad51</i> leads to Fanconi anemia-like symptoms in zebrafish

2016-12-20

Abstract excerpt

RAD51 is an indispensable homologous recombination protein, necessary for strand invasion and crossing over. It has recently been designated as a Fanconi anemia (FA) gene, following the discovery of two patients carrying dominant negative mutations. FA is a hereditary DNA repair disorder characterized by various congenital abnormalities, progressive bone marrow failure and cancer predisposition. In this paper, we...

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Literature Corpus work: 6d3e09a0-cd1f-5867-8ae2-5dd9ad303f56
DOI: 10.1101/095646

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